According to ANOVA, the most valid parameters for the discrimination of patients with RA from control subjects were ACPA, CRP, m-csbDNA, and RF levels (F = 48.4, Pr < 0.001, F = 30.3, Pr < 0.001; F = 17.7, Pr < 0.001, and F = 16.3, Pr < 0.001, respectively), whereas n-csbDNA, n-cirDNA, and m-cirDNA possessed lower power for discrimination of patients and control subjects (Table 3). This evidence concerns the gene CRP and rheumatoid arthritis.