HSPA5 and chronic obstructive pulmonary disease: Glucose regulated protein of 78 kD (i.e., GRP78), an ER chaperone required for the processing and transport of key lung proteins (e.g., CFTR and surfactant protein C) [9–11] is up-regulated in the lung by cigarette smoke [8] and has been reported as a potential biomarker for COPD [2, 12].