AFP and neoplasm: Moreover, tumor-related factors, including a seral AFP level > 20 ng/ml (OR = 2.51, P < 0.001), multiple lesions (OR = 2.18, P = 0.038), tumor size >3 cm (OR = 1.73, P = 0.035), Edmonson grades III/IV (OR = 2.48, P = 0.013) and incomplete/absent tumor capsule (OR = 2.17, P = 0.006), were significantly and independently associated with vascular invasion.