In the Lund cohort, the SUMF1 mRNA levels, of total SUMF1 and the different splice variants, were examined in sputum cells from controls and COPD patients as well as in lung fibroblasts from COPD patients in relation to the SUMF1 genotypes of SNPs rs11915920 and rs793391. The gene discussed is SUMF1; the disease is chronic obstructive pulmonary disease.