The cell death induced in neuroblastoma cells after Adenovirus-LAPTM5 (Ad-LAPTM5) infection is not blocked by the pan-caspase inhibitor z-VAD-fmk, but is enhanced in the presence of both proteasomal and lysosomal inhibitors, causing the accumulation of LAPTM5-positive vesicles. The gene discussed is LAPTM5; the disease is neuroblastoma.