Furthermore, in the Phase 1 trial of Na-GST-1/Alhydrogel conducted in Brazil that is reported herein, none of the adult volunteers who were screened for the study had detectable IgE antibodies to Na-GST-1, further adding to the body of evidence that this antigen does not induce sensitization during natural hookworm infection. The gene discussed is IGHE; the disease is ancylostomiasis.