In the present study, we quantified two functional components in PAMs and showed that PAMs could inhibit the TNF-α/IFN-γ-induced inflammatory cytokines production in HaCaT cells and ameliorate imiquimod-induced psoriasis-like skin inflammation in mice by inhibiting the translocation of p65 in NF-κB signaling pathways. The gene discussed is TNF; the disease is dermatitis.