Furthermore, single nucleotide polymorphisms (SNPs) in IL-12A (rs2243115 and rs568408) [46], IL-12B (rs3212227) [46], and IL-23 receptor gene (rs10889677 and rs1884444) [47] were associated with the risk of AD in a Chinese population, suggesting that the genes encoding IL-12 and IL-23 receptor could be risk factors for late-onset AD susceptibility [46, 47]. The gene discussed is IL12B; the disease is Alzheimer disease.