NPSR1 and asthma: Based on the effects of the NPS SNP rs4751440 on genetic asthma risk and NPSR1 signaling, we first tested genetic association of 29 NPSR1 SNPs with physician-diagnosed childhood asthma in BAMSE (n = 2033), and then assessed epistasis between NPS and NPSR1. We detected significant association between three NPSR1 SNPs (rs887020, rs2531840 and rs11770777) with asthma (p<0.05) and confirmed that the functional rs324981 (T>A) encoding for NPSR1-Ile(107) and NPSR1-Asn(107) had no significant main effects at present resolution (S2 Table).