The next aim was to investigate if the effects of NPS SNPs (rs1931704, rs10830123 and rs4751440) on the risk of asthma were modified by the carrier status of alleles in the SNP rs324981 (A>T) encoding for NPSR1-Asn(107) and NPSR1-Ile(107), respectively, or by other variants with previous evidence of putative functional effects in the NPSR1 gene. The gene discussed is NPS; the disease is asthma.