Although the latter had significant main effects on asthma risk and proved to be functional in the cell assays, a lower frequency of informative GC heterozygotes in the patient group could have influenced the power to detect gene-gene interactions with NPSR1. Indeed, 24% of non-asthmatic children were heterozygous for NPS rs4751440 and there was a low frequency of CC carriers in the cohorts with only 2% of children being homozygous (CC) for NPS-Leu(6). Here, NPS is linked to asthma.