Interestingly, phosphorylation of ERK was not impaired by FAM83A knockdown in HCC1954 cells, implicating that FAM83A may signal primarily through the PI3K/Akt pathways in HER2+ BC as opposed to signaling through both the MAPK and PI3K/Akt pathways in TNBCs [32, 33]. Here, AKT1 is linked to breast cancer.