Moreover, it is tempting to speculate, that such anxiogenic effects may be mediated through activity of dopamine D1 receptors since the intra-amygdaloid administration of SCH-23390, a selective D1 receptor antagonist, attenuated anxiety in Leprdat-Cre mice [58] and induces anxiolytic responses in rats subjected both to the LDBT [67], the EPM [68] and the SPBT [69]. The gene discussed is DRD1; the disease is Anxiety.