As expected, the results revealed that the protein levels of Mfn2 (P=0.002) and Opa1 (P=0.021) were significantly decreased in BD patients compared with the controls (Figures 2d and f, respectively), whereas the protein levels of Fis1 (P=0.036) were significantly increased in lymphocytes from the BD group when compared with healthy controls (Figure 3b). This evidence concerns the gene FIS1 and Behcet disease.