In this study, we have investigated the levels of several survival-related and pro-apoptotic proteins in PBMCs of BD participants, and we observed significant alterations compared to healthy controls, including marked decreases in the levels of Bcl-xL, survivin and Bcl-xL/Bak dimers and an increase in the caspase-3 protein levels. The gene discussed is CASP3; the disease is Behcet disease.