Increased PDE2A expression was reported both in rodents (Hua et al., 2012) and in human (Aye et al., 2012) heart failure and PDE2A inhibition was shown to reduce cardiac hypertrophic remodelling in a mouse model of cardiac hypertrophy (Zoccarato et al., 2015), indicating that PDE2A inhibition may be of therapeutic value in this context. This evidence concerns the gene PDE2A and cardiac hypertrophy.