SOD1 and amyotrophic lateral sclerosis: Misfolded wt-SOD1 also shares this feature, which supports the controversial proposition that misfolding of wt-SOD1 is involved in pathogenesis of sporadic ALS (Rotunno and Bosco, 2013; van Zundert and Brown, 2017; Ayers et al., 2016; Grad et al., 2014).