Namely, inactivation of the TIF-IA gene in striatal MSNs (TIF-IAD1RCre mice) recapitulates the phenotypic alterations associated with selective striatal neurodegeneration (occurring in 13-week-old mice), including increased oxidative damage and inflammatory response, finally leading to MSN cell death and resulting in an HD-like phenotype (Kreiner et al., 2013). The gene discussed is RRN3; the disease is Huntington disease.