Conversely, overexpression of seladin-1 (for example, in responseto estrogen administration) accelerates cholesterol metabolism in the brain andincreases neurons’ resistance to Aβ [40].Interestingly, caveolin 1 gene knockout (caveolin 1stabilizes the membrane rafts) leads to a pathology, similar to that observedin AD, which is accompanied by Aβ accumulation and neurodegeneration. The gene discussed is DHCR24; the disease is Alzheimer disease.