This reduces APP cleavage by the γ- and β-secretasesthat prefer to use APP dimers as a substrate [54].LRP10 and SorLA enhance APP traffic to the Golgi complex,where the secretases are less active [55].Weak ABCA1 activity may contribute to AD, whereas itsoverexpression reduces the accumulation of Aβ. This evidence concerns the gene APP and Alzheimer disease.