ERBB2 and breast carcinoma: However, when low-dose aspirin was considered separately, current use of three or more tablets per week of low-dose aspirin was statistically significantly associated with risk of breast cancer overall (HRR = 0.84, 95% CI 0.72–0.98 compared to those not taking any NSAIDS); this association was observed only for the HR-positive/HER2-negative subtype (HRR = 0.80, 95% CI 0.66–0.96).