These findings of select drug response profiles of hereditary SB.mhdgc-1 gastric cancer cells to MEK and mTOR inhibition, in combination with gene expression dysregulation of ERK and phosphoinositide-mediated signaling networks, also appear to be in line with elevated phospho-ERK: total ERK and phospho-Akt (T308): total Akt ratios observed as a measure of dysregulated signal transduction activity in SB.mhdgc-1 cells. Here, AKT1 is linked to gastric cancer.