Phospho-ERK-to-total ERK, and phospho-Akt-to-total AKT ratios were elevated in c.1380delA CDH1 SB.mhdgc.-1 gastric cancer cells compared to a panel of six heterogenous sporadic gastric cancer lines (Fig. 3e), a finding in line with above gene set enrichment analysis identifying ERK1/ERK2 network as top network enriched in SB.mhdgc-1 cells. The gene discussed is AKT1; the disease is gastric cancer.