Using the patient-derived c.1380delA CDH1 SB.mhdgc-1 and SB.msgc-1 tissue culture lines, and an extended panel of sporadic gastric cancer cell lines, combined comparative gene expression profiling and qHTS drug screening with a large oncology library identified leads with selective activity in familial gastric cancer cells occurring in the context of CDH1 germline mutations. The gene discussed is CDH1; the disease is gastric cancer.