PDK1 and gastric cancer: Albeit not different to sporadic gastric cancer cell lines N87 and SNU16, c.1380delA CDH1 SB.mhdgc-1 cells showed activation of the Akt-upstream regulator and PIP3 sensor 3-phosphoinositide dependent protein kinase-1 (PDK1, measured as serine 241 phosphorylation), a finding consistent with elevated PIP3 levels in SB.mhdgc-1 cells compared to SB.msgc-1 cells.