GO analysis identified upregulation of ERK and phosphoinositide-mediated signaling network processes in hereditary c.1380delA CDH1 SB.mhdgc-1 gastric cancer cells which showed selective sensitivities to different drug classes including mTOR, MEK as well as c-Src, FAK, or topoisomerase II inhibiting agents. The gene discussed is CDH1; the disease is gastric cancer.