In order to identify treatment leads selective for the HDGC subtype due to CDH1 germline mutations of gastric cancer, we derived a primary tissue culture line from an HDGC patient with a c.1380delA CDH1 truncating germline mutation leading to loss of CDH1 expression, and compared the transcriptomic profile and drug sensitivity profile of these cells to a panel of sporadic gastric cancer cells. This evidence concerns the gene CDH1 and gastric cancer.