As the MCF10A CDH1(−/−) isogenic system captures predominantly early vulnerabilities with predominantly chemopreventative translational value, it is thus not known if the synthetic lethalities and drug sensitivities discovered to selectively occur in the CDH1(−/−) mutants capture vulnerabilities of E-cadherin deficient gastric cancers in a more evolved stage which might harbor greater therapeutic value. Here, CDH1 is linked to gastric cancer.