Similarly, the recently released data from The Cancer Genome Atlas (TCGA) initiative suggests genomically defined leads, for example, of increased sensitivity to receptor tyrosine kinase or cell cycle modulating agents in the chromosomal unstable (CIN) identified gastric cancers, or increased sensitivity to PI3K kinase, JAK2, and immune checkpoint blockade in the EBV positive subtype [25]. The gene discussed is JAK2; the disease is gastric cancer.