It is thus perceivable that the MCF10A system, which is not tumorigenic per se and has no oncogenic addiction, represents the very early intramucosal T1a stage in the slow proliferating phase with no, or limited, response to inhibitors c-Src inhibitors but capturing the perturbations associated with defective CDH1 adhesion and cell polarity signaling, whereas the transformed c.1380delA CDH1 SB.mhdgc-1 cells derived from the ascites of the HDGC patient with diffuse gastric cancer are dependent on c-Src, MAPK kinase, or other late occurring signal transduction signaling aberrations [12, 28]. The gene discussed is CDH1; the disease is Familial gastric cancer.