PIK3R3 and non-small cell lung carcinoma: Similarly, miR-193a has been identified as an inhibitor of NSCLC metastasis by downregulating the ERBB4/PIK3R3/mTOR/S6K2 signaling pathway and miR-29b has been shown to suppress proliferation, migration and invasion abilities of lung cancer cells by targeting PTEN and MMP2, as well as being significantly associated with lymph node metastasis in NSCLC [22, 23].