To explore whether hispidin can cause cell death in other cancer cells as it did in SGC-7901 cells, we treated A549 and HepG2 cancer cells and L02 normal cells with hispidin and examined cell viability (Supplementary Figure 5A to 5C), cell death (Supplementary Figure 5D), morphological changes (Supplementary Figure 5E), LMP (Supplementary Figure 5F) and tubulin depolymerization (Supplementary Figure 5G). This evidence concerns the gene PDLIM7 and cancer.