SKP2 and familial pancreatic carcinoma: In pancreatic cancer cells, the ICG-001-mediated effect on cell cycle had been linked to genes particularly involved in G0/S1-phase transition: Cell Division Cycle25A (CDC25A), S-Phase Kinase-Associated Protein 2 (SKP2) and Cyclin dependent Kinase Inhibitor1A (CDKN1A) were all downregulated upon ICG-001 treatment; CDKN1A was identified as direct target of CBP [27].