As shown in Figure 3A and 3B, the enediyne-energized analogues of four fusion proteins EGF-LDP-AE, LDP-IGF-AE, EGF-LDP-IGF-AE and EGF-IGF-LDP-AE displayed extremely potent cytotoxicity to NSCLC cell lines A549, H460, H520 and H1299. The gene discussed is CPQ; the disease is non-small cell lung carcinoma.