KRAS and metastatic colorectal cancer: A clinical trial by Siena et al. [28] showed the efficacy and safety of a combination treatment with lenalidomide and cetuximab in KRAS (v-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog)-mutant metastatic colorectal cancer patients and implicated lenalidomide as an activator of T cells, which may play a role in its antitumor activity.