In line with the reduction in cell viability, all five NSCLC cell lines transfected with HAS2, or RHAMM siRNA and four cell lines transfected with CD44 exhibited suppression of CD44, RHAMM, and total- and phosphorylated-EGFR, Akt and ERK, whereas the pro-apoptotic proteins caspase 3 and PARP were activated in most of the cell lines as evidenced by enhanced cleavage (Figure 3B). Here, CASP3 is linked to non-small cell lung carcinoma.