HMMR and non-small cell lung carcinoma: In order to further assess the role of the HA-CD44/RHAMM signaling in the growth and survival of NSCLC cells, we transfected the cells with HAS2, CD44 or RHAMM specific siRNAs or scrambled siRNA and effects on cell viability and expression of cell proliferation- and apoptosis-related proteins were determined.