In particular, lung cancer tissues showed intense RHAMM protein expression in 96% of metastatic non-small cell lung cancer (NSCLC) cases [15] and RHAMM mRNA expression was 12- and 10-fold higher in lung adenocarcinoma and squamous lung carcinoma than in matched normal lung tissues, respectively [16]. This evidence concerns the gene HMMR and non-small cell lung carcinoma.