AKT3 and acute myeloid leukemia: In acute myeloid leukemia, miR-29b-1 (part of the miR-29a cluster, and knocked out in the miR-29a-deficient mice) is downregulated, contributing to the loss of normal granulopoiesis [24], and likewise in thyroid cancer miR-29a appears to be a tumour-suppressor-miR, with loss removing AKT3 regulation [25].