As shown in Figure 6A, in NCI-H508 xenograft models, AdC7-ΔE3 and AdC7-SP/E1A-ΔE3 groups induced dramatic declines in tumor volume relative to control groups (PBS group, AdC7-ΔE1A-ΔE3), while AdC7-ΔE3 and AdC7-SP/E1A-ΔE3 groups had no significant difference in tumor volume. This evidence concerns the gene DHTKD1 and neoplasm.