DHTKD1 and neoplasm: As shown in Figure 2A–2D, we confirmed that AdC7-SP/E1A-ΔE3 could replicate in a panel of tumor cell lines (NCI-H508, Huh7, A549, or SiHa); relative viral genome copy numbers were significantly higher in cells infected with AdC7-SP/E1A-ΔE3 than in cells infected with AdC7-ΔE1A-ΔE3 (p < 0.0001).