To test this hypothesis, a panel of tumor cells was infected, at 10 MOI, with AdC7-ΔE1A-ΔE3, AdC7-ΔE3, or AdC7-SP/E1A-ΔE3, and relative viral genome copy numbers, which served as the readout for viral replication, were detected by RT-PCR. This evidence concerns the gene DHTKD1 and neoplasm.