PTEN and neoplasm: As the oncogene SET is a potent inhibitor of the tumour suppressor PP2A [16, 17], and inhibits other tumour suppressors such as PTEN [18] and TP53 [19], we examined how SET accumulation affects DNA methylation using a panel of known tumour suppressor genes by means of EpiTect Methyl qPCR arrays (Figure 1A).