Moreover, there was no significant difference between CT26/HER2 tumor-bearing and 4T1.2/HER2 tumor-bearing mice with respect to the populations of MDSCs, DCs and Treg cells in the TDLNs, suggesting that MDSCs, DCs and Treg cells may not be associated with the regulation of Ag-specific CTL induction in CT26/HER2 tumor-bearing mice. The gene discussed is DDX53; the disease is neoplasm.