CDC42 levels in tumor samples did not correlate with prognosis, however we found that three genes have an improved prognostic value when combined with CDC42 status: LARS2, REG1CP and CACNA2D2. Inactivation of LARS2 (leucyl-tRNA synthetase in mitochondria) has been described in nasopharyngeal cancer cells [33], and dysregulation of aminoacyl-tRNA synthesis has also been widely linked to tumorigenesis [34], however this is the first report showing a transcriptional link between CDC42 and LARS2 in CRC. This evidence concerns the gene LARS2 and neoplasm.