CDC42 overexpressing cells (CDC42ov) only showed a modest up-regulation compared to the parental cell line SW620 (Figure 1A and Supplementary Figure 1A), which already had high CDC42 basal levels compared to other CRC cell lines as well as to a primary colon fibroblast cell line, CCD-18Co (Supplementary Figure 1B). Here, CDC42 is linked to colorectal carcinoma.