To investigated the role of activated p38 (p-p38) in human cancer development, we analyzed the level of phosphorylated and activated p38 in human lung tumor samples using a tissue array containing 153 intact NSCLC tumor tissues (79 squamous cell carcinoma and 74 adenocarcinoma) and 31 intact normal lung tissues/normal adjacent lung tissue (NAT) (18 normal lung tissue and 13 NAT). The gene discussed is BRD2; the disease is cancer.