Indeed, the expression of two marker genes of ER-stress and UPR, GRP78/BiP and CHOP [18, 19], was greatly enhanced upon treatment with tunicamycin within the dose-range found to be cytotoxic for the FLT3ITD expressing human AML cell lines (Figure 2C, 2D). This evidence concerns the gene DDIT3 and acute myeloid leukemia.