Although Scrib has been shown to regulate other oncogenes and tumor suppressors such as β-catenin, Akt and PTEN [9, 41, 48], we did not detect any changes in their expression or activity in response to Scrib-OE, suggesting that Scrib inhibits liver cancer cell growth by mainly suppressing Yap1 and c-Myc, and consequently their downstream target genes such as cyclin D1, Enolase 1, Aldolase and LDH, which aid cancer cells in proliferation and metabolic reprogramming. This evidence concerns the gene PTEN and liver cancer.