Although Scrib has been shown to regulate other oncogenes and tumor suppressors such as β-catenin, Akt and PTEN [9, 41, 48], we did not detect any changes in their expression or activity in response to Scrib-OE, suggesting that Scrib inhibits liver cancer cell growth by mainly suppressing Yap1 and c-Myc, and consequently their downstream target genes such as cyclin D1, Enolase 1, Aldolase and LDH, which aid cancer cells in proliferation and metabolic reprogramming. Here, PTEN is linked to neoplasm.