SPHK1 and cancer: Using the Kaplan-Meier analysis, data from The Cancer Genome Atlas (TCGA) of 607 patients with serous ovarian cystadenomas showed that the reduced SPHK1&2 mRNA levels (lower than the two-thirds) are associated with increased month disease free rates and increased month overall survival rates in this cancer type (Supplementary Figures 1B and 1C).