Notably, the pathway analysis revealed that systemic lupus erythematosus signaling was the top modulated canonical pathway following RAB10 knockdown (P < 10−7; Figure 3B), and that a RAB10-mediated gene interaction network was among the most significant gene networks following topological arrangement of the differentially expressed genes by GeneSpring GX software (Figure 3C and 3D). Here, RAB10 is linked to systemic lupus erythematosus.