Literature data have widely proven that TMEM106B variants are genetically associated to frontotemporal lobar degeneration–TDP-43 pathology and are considered a major risk factor for this disease (Chen-Plotkin et al., 2012; Busch et al., 2013; Nicholson and Rademakers, 2016). The gene discussed is TMEM106B; the disease is frontotemporal dementia.