INS and type 2 diabetes mellitus: The purpose of this study was to determine whether: 1) CKD leads to insulin resistance in a nephrectomised rat model of CKD, 2) CKD modulates key transporters involved in glucose homeostasis which could ultimately lead to insulin resistance, 3) CKD is associated with impaired glucose uptake in insulin-sensitive organs and 4) insulin resistance in CKD leads to T2D.