In addition, changes in glucose transporter mRNA expression (Fig 3C) in CTL and CKD Zucker rats were similar to that observed in SD rats in the muscle (GLUT1 decrease of 26%, p<0.05; GLUT4 decrease of 25%, p<0.01) and adipose tissue (GLUT1 increase of 70%, p<0.05; GLUT4 increase of 23%, N.S.). This evidence concerns the gene SLC2A4 and chronic kidney disease.