Compared to late stage non-tumor BAT samples of DAKO mice, Gene Set Enrichment Analysis for Reactome pathway in DAKO liposarcomas revealed that the pathway with the greatest relative up-regulation of gene expression in DAKO liposarcomas was angiogenesis (S6B Fig), In this pathway, the highest up-regulation was seen for Esm1, encoding Endocan, expression of which has been reported to be increased up to 30-fold in human liposarcoma (SW872) cell lines [30, 31]. This evidence concerns the gene ESM1 and liposarcoma.