Intriguingly, although N1ICP-related liposarcomas occur in white adipocytes whereas DAKO liposarcoma occurs in brown adipose tissue, both the DAKO and N1ICP-related liposarcomas occur with complete penetrance, and in both, intracellular fatty acid pools and PPAR-γ signaling are predicted to be reduced. This evidence concerns the gene PPARG and liposarcoma.