For example, although the majority of coronary artery disease (CAD) associated loci showed similar effect sizes in analyses based on the subset of cases with myocardial infarction alone versus a broader CAD phenotype (coronary stenosis >50%, acute coronary syndrome and chronic stable angina), discrepant effect sizes were evident at the HDAC9 and ABO loci [3]. Here, ABO is linked to coronary artery disorder.