Low expression of miR-34c has been reported in several cancers including breast, lung, pancreatic, brain, ovarian, laryngeal and prostate cancers.68, 69, 77, 78, 79, 80 Some studies also demonstrated downregulation of miR-34c in breast and prostate cancer stem cells and the roles of miR-34c to suppress cancer stemness via targeting p53 and Notch genes but have never linked to AREG.27, 81, 82 The role of miR-34c-5p in ovarian cancer stem cells has never been reported before and information on its regulatory role on AREG is also lacking. Here, TP53 is linked to Familial prostate cancer.