AREG and cancer: AREG has been suggested as a good target for treating cancer, inhibition of AREG by siRNA or monoclonal antibodies results in apoptosis of cancer cells or shrinkage of mice xenograft tumors.15, 61, 83 Our study showed that transfection of SKOV-I6 cells with miR-34c-5p resulted in significant decrease of tumor volumes in NOD/SCID mice.