Another key nuclear receptor common to all three tissues wasNR5A1 (also known as steroidogenic factor-1), responsible for adrenal insufficiency, testicular dysgenesis and primary ovarian insufficiency (Achermannet al., 1999;Lourençoet al., 2009;Suntharalinghamet al., 2015). Here, NR5A1 is linked to Adrenal insufficiency.