ZNF280B and Familial prostate cancer: Amongst the other key genes identified,ZNF280B has been proposed to encode a negative regulator of p53 in prostate cancer cells (Gaoet al., 2013), whereasPRPS2 encodes a testis specific phosphoribosylpyrophosphate synthetase that may function as an anti-apoptotic factor (Leiet al., 2015;Tairaet al., 1990).