MC2R and Adrenal insufficiency: These conditions may be precipitated by postnatal stress and affected children very rarely present with adrenal insufficiency in early infancy, unlike other conditions associated with differentially expressed genes where children often present in the neonatal period (e.g.NR0B1,NR5A1, SAMD9,CDKN1C,MRAP,MC2R,STAR,CYP11A1,HSD3B2,CYP17A1,POR,CYP21A2,CYP11B1) (Guranet al., 2016).