However, reports from some studies using animal models and humans have suggested detrimental health effects such as accelerated atherosclerosis, poorer endothelial function and elevated arterial stiffness, elevation of some cardiovascular risk factors such as fibrinogen, lipoprotein (a), and C-reactive protein (CRP), and association with elevated all-cause mortality risk [5–8]. The gene discussed is CRP; the disease is atherosclerosis.