Pin1 activity often translates to a fate-determining ubiquitination switch, and Pin1 may likewise affect the degree of ubiquitination in the degradation of PSD proteins (Figure 4) including PSD95, GKAP, Shank, and other proteins involved in the disruption of the PSD in AD [21, 28, 46, 47]. The gene discussed is DLGAP1; the disease is Alzheimer disease.