Of these, 23 cross-sectional and 10 prospective studies were included in a 2006 systematic review and meta-analysis by Ding et al. [1] which reported that a higher concentration of SHBG was associated with a lower risk of development of T2DM, and that this relation was stronger for post-menopausal women than for men. The gene discussed is SHBG; the disease is type 2 diabetes mellitus.