WT1 gene, as a transcription factor, directly or indirectly interacts with a number of genes involved in cell cycle and neoplasia, including HIF1A, AREG, SRY, NROB1, SOX9, IGF2, MDM4, BRCA1, TP53, and SP1 (NCBI Gene). The gene discussed is AREG; the disease is neoplasm.