NRXN3 is highly expressed in normal tissues and down-regulated in human gliomas; moreover, Sun et al. (2013) found that Forkhead box Q1 (FoxQ1) promotes glioma proliferation by down-regulating NRXN3, suggesting that it may be a tumor suppressor gene (Sun et al., 2013). Here, NRXN3 is linked to central nervous system cancer.