Since an imbalance in the subsets of CD4+ T cells was found in the EAE model and MS patients (Dittel, 2008; Hoglund and Maghazachi, 2014; Dendrou et al., 2015), we investigated the population of Th1 (CD4+/IFN-γ+), Th2 (CD4+/IL-4+), Th17 (CD4+/IL-17+), and Treg (CD4+/Foxp3+) cells in the spinal cord. This evidence concerns the gene CD4 and myeloid sarcoma.