In MS and EAE, activated immune cells from the periphery, such as autoreactive T cells, may migrate into the CNS through the BBB and produce pro-inflammatory chemokines/cytokines leading to the activation of astrocytes, cellular adhesion molecules (ICAM-1, VCAM-1, etc.), and junctional molecules (zona occludens-1, claudin-3, claudin-5, etc.)between/or around the endothelial cells (Fabis et al., 2007; Steiner et al., 2010; Pfeiffer et al., 2011; Kawakami et al., 2012). This evidence concerns the gene CLDN5 and myeloid sarcoma.