Interestingly, although PINK1 mutation carriers are clinically indistinguishable from Parkin mutation carriers, frequency of depression is higher in PINK1 carriers, calling for more detailed anatomical comparisons between these two diseases (Schneider and Klein, 2010; Ricciardi et al., 2014; Chaudhuri et al., 2015). Here, PINK1 is linked to major depressive disorder.