Motor symptoms of PD patients with two Parkin mutations present with classic parkinsonism, slow disease progression and more symmetrical onset, with fewer NMS than classic PD (Lesage and Brice, 2009; Lohmann et al., 2009; Kasten et al., 2010), supporting the concept of limited pathology (Kägi et al., 2010). Here, PRKN is linked to Parkinson disease.