In insulinoma-derived MIN6 cells, we see that 6S-A Ngn3 is five times as stable as WT Ngn3 (half-life 52.3 ± 7.9 min compared with 11.7 ± 2.8 min) (Figures 5A, 5B, and 5D). This evidence concerns the gene NEUROG3 and pancreatic insulinoma.