However, deletion of TLR7 in Wiskott-Aldrich syndrome protein (WASp) in mice inhibited systemic autoimmunity, whereas deletion of TLR9 promoted systemic autoimmunity which recapitulates the phenotype seen in TLR7/9-deficient lupus mice [212–214]. The gene discussed is TLR9; the disease is systemic lupus erythematosus.