NK cells stimulated with optimal doses of rIL-15 displayed cytotoxicity against all MM-associated endothelial cells analyzed, an effect that was accompanied by the upregulated expression of CD69 activation marker (Figure 3B and 3C), NKG2D (Figure 3D) and NKp30 (Figure 3E) and by a modest but significant production of IFN-γ (Figure 3H). The gene discussed is CD69; the disease is Miyoshi myopathy.